Wiersbe – who came to Christ after hearing Billy Graham preach at a Youth for Christ rally – became an ordained minister in 1951 from the Northern Baptist Theological Seminary in Lombard, Illinois.
After receiving his ordination, Wiersbe began pastoring at Central Baptist Church in East Chicago, Indiana until 1957.
From 1961 to 1971, Wiersbe pastored at Calvary Baptist Church in Covington, Kentucky before becoming the pastor at Moody Memorial Church in Chicago from 1971 to 1980.
While at Moody Memorial Church, Wiersbe’s sermons were broadcasted on the church’s radio station, he regularly wrote for the church’s newsletter, and the prolific pastor began to teach and develop a curriculum for a DM in preaching at Trinity Evangelical Divinity School. During this time, Wiersbe also began to mentor up and coming pastors.
According to the Baptist Press, after leaving Moody, Wiersbe continued writing, sharing his sermons via radio and teaching.
Wiersbe is regarded by many as a mentor, a friend, a champion for the Christian faith and remarkable preacher.